| Main Title |
Myelin Basic Protein-Messenger RNA (MBP-mRNA) Expression during Triethyltin-Induced Myelin Edema. |
| Author |
Veronesi, B. ;
Jones, K. ;
Gupta, S. ;
Pringle, J. ;
Mezei, C. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. ;Dalhousie Univ., Halifax (Nova Scotia). Dept. of Biochemistry. |
| Publisher |
c1991 |
| Year Published |
1991 |
| Report Number |
EPA/600/J-92/072; |
| Stock Number |
PB92-150861 |
| Additional Subjects |
Encephalitogenic basic proteins ;
Messenger RNA ;
Gene expression ;
Edema ;
Trimethyltin compounds ;
Toxicity ;
Rats ;
Brain ;
Nucleic acid hybridization ;
Northern blotting ;
Electron microscopy ;
DNA probes ;
Optic nerve ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB92-150861 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
14p |
| Abstract |
Triethyltin (TET) is a neurotoxicant that produces severe but transient cerebral edema, characterized ultrastructurally by vacuolation of the intraperiod line of central nervous system (CNS) myelin. In the present study, the genomic expression (i.e., mRNA) of MBP was monitored throughout the pathogenesis of TET-induced myelin edema and recovery in Sprague-Dawley rats given a single injection of a neuropathic (8.0 mg/kg) or non-neuropathic (0.8 mg/kg) dose of TET-bromide. Levels of MBP-mRNA from the anterior and posterior brain were collected 1 hr, 3 hr, 2d, and 7d, postexposure. The optic nerve andd caudal brainstem, representing anterior and posterior brain sites, respectively, were examined at the same time-points for ultrastructural evidence of edema and recovery. Study data indicate that neuropathic doses (8.0 mg/kg) of TET significantly stimulated MBP transcript throughout the brain at all exposure time-points. The magnitude and time-course of this stimulation differed in the anterior and posterior brain, with the latter region showing higher levels of MBP-mRNA. |
| Supplementary Notes |
Pub. in Neurotoxicology, v12 n2 p265-276 Jul 91. See also PB91-231274. Prepared in cooperation with Dalhousie Univ., Halifax (Nova Scotia). Dept. of Biochemistry. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Myelin Basic Protein-Messenger RNA (MBP-mRNA) Expression during Triethyltin-Induced Myelin Edema. |
| Category Codes |
57F; 57Y |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
211522994 |
| Origin |
NTIS |
| Type |
CAT |
