| Main Title |
Evaluation of Dowanol Pm in the Rat Hepatocyte Unscheduled DNA Synthesis Assay. |
| CORP Author |
Dow Chemical Co., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
2000 |
| Report Number |
86-890001234 |
| Stock Number |
OTS0520744 |
| Additional Subjects |
Toxicology ;
Health effects ;
1-methoxy-2-propanol (107-98-2) ;
Genotoxicity ;
DNA Effects ;
Mammals ;
Rats ;
In Vitro ;
Toxic substances ;
Laboratory animals ;
CAS No 107-98-2
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0520744 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
14p |
| Abstract |
Genotoxicity of 1-methoxy- 2-propanol was evaluated in the rat hepatocyte primary culture/DNA repair assay. The compound was tested at concentrations of 3.16x10E-5, 1x10E-4, 3.16x10E-4, 1x10E-3, 3.16x10E-3, 1x10E-2, 3.16x10E-2, and 1x10E-1 M, in Williams Medium E with 10% fetal calf serum. The negative control and positive control groups were cell cultures exposed to the media only, or the media plus 2- acetylaminofluorene (1x10E-7, 1x10E-6, or 1x10E-5 M) in 1% DMSO, respectively. The treatment was cytotoxic to the cell cultures at 3.16x10E-2 and 1x10E-1 M. The treatment had no effect on the rate of DNA repair, indicating a lack of genotoxicity of 1-methoxy-2- propanol in this cell culture assay. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
2000 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028802210 |
| Origin |
NTIS |
| Type |
CAT |
