| Main Title |
Initial Submission: Acute Toxicity Study with Cyanogen Bromide in Rats (Final Report) with Cover Letter dated 07/24/92. |
| CORP Author |
Dow Chemical Co., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1992 |
| Report Number |
88-920005758 |
| Stock Number |
OTS0544541 |
| Additional Subjects |
Toxicology ;
Health effects ;
Cyanogen Bromide ;
Acute Toxicity ;
Mammals ;
Rats ;
Inhalation ;
Toxic substances ;
Laboratory animals ;
CAS No 506-68-3
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0544541 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
10p |
| Abstract |
Cyanogen bromide (CAS No. 506-68-3) was evaluated for acute inhalation toxicity. The test substance was administered to groups of 10 male and 10 female Sprague Dawley rats. Concentration, duration, and mortality data are as follows: 10 ppm for 6-hours (0/8 M, 0/8 F); 35 ppm for 6-hours (0/8 M, 0/8 F); 45 ppm for 6-hours (8/8 M, 2/8 F); 56 ppm for 6-hours (8/10 M, 10/10 F); and 112 ppm for 2.5-hours (10/10 M, 10/10 F). There were no adverse effects at 10 ppm and transient nasal irritation at 35 ppm. There were no treatment-related lesions at necropsy below 35 ppm. Clinical signs above 35 ppm included moderate to severe respiratory tract irritation, with rats gasping for breath during and after exposure, and severe weight loss with a slow recovery. Necropsy findings revealed severe respiratory tract irritation, congested lungs and liver, and distended stomachs due to mouth breathing. The LC50 was determined to be 39.3 ppm for males and 52.7 ppm for females. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1992 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A02/MF A02 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028803600 |
| Origin |
NTIS |
| Type |
CAT |
