||Glucocorticoids Regulate the Synthesis of Glial Fibrillary Acidic Protein in Intact and Adrenalectomized Rats but Do Not Affect Its Expression Following Brain Injury.
O'Callaghan, J. P. ;
Brinton, R. E. ;
McEwen, B. S. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Rockefeller Univ., New York.
Glial fibrillary acidic protein ;
Stains and staining ;
Cerebral cortex ;
Microtubule-associated proteins ;
Deoxyribonucleic acids ;
Northern blotting ;
Brain injuries ;
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||Short (5 days)-to long-term (4 months) corticosterone (CORT) administration by injection, pellet implantation, or in the drinking water decreased glial fibrillary acidic protein (GFAP) by 20-40% in hippocampus and cortex of intact rats. In contrast to CORT, adrenalectomy (ADX) caused elevations (50-125%) in hippocampus and cortex GFAP within 12 days of surgery that persisted for at least 4 months. CORT replacement of ADX rats decreased GFAP amount in hippocampus and cortex. The effects of long-term CORT and ADX on GFAP in hippocampus and cortex were also seen in striatum, midbrain, and cerebellum, findings suggestive of brain-wide adrenal steroid regulation of the astrocyte protein. The changes in GFAP amount due to CORT and ADX were paralleled by changes in GFAP mRNA, indicating a possible transcriptional or at least genomic effect of adrenal steroids. (Copyright (c) 1991 International Society for Neurochemistry.)
||Pub. in Jnl. of Neurochemistry, v57 n3 p860-869 Sep 91. Prepared in cooperation with Rockefeller Univ., New York.
|NTIS Title Notes
||Reprint: Glucocorticoids Regulate the Synthesis of Glial Fibrillary Acidic Protein in Intact and Adrenalectomized Rats but Do Not Affect Its Expression Following Brain Injury.
||57Q; 57B; 57S; 57X
||PC A03/MF A01