| Main Title |
Initial Submission: Letter from Rohm and Haas Company to USEPA re: Neurotoxicity in Female Rats with Ethyl 4,4,4-trifluoroaceto-acetate, in Preliminary Results of Acute Study, with Cover Letter dated 10/05/99. |
| CORP Author |
Rohm and Haas Co., Philadelphia, PA.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
7 Oct 1999 |
| Year Published |
1999 |
| Report Number |
8EHQ-1099-14563; |
| Stock Number |
OTS-0559810 |
| Additional Subjects |
Toxicity ;
Neurotoxicity ;
Females ;
Rats ;
Corn oil ;
Gavage ;
Dosage ;
Laboratory animals ;
Ethyl 4,4,44rifluoroacetoacetate ;
Acute toxicity tests ;
CAS No 372-31-6
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0559810 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
6p |
| Abstract |
This letter transmits preliminary results of an acute toxicity test indicating neurotoxic effects to female rats for ethyl 4,4,44rifluoroacetoacetate (CAS No. 372-31-6). Ethyl 4,4,4-trifluoroacetoacetate (ETFAA) was suspended in corn oil and administered by oral gavage to seven groups of six female rats/group at dose levels of 0, 25, 100, 17.5, 250, 500, or 750 mg/kg of body weight at a constant volume of 5 ml/kg. Clinical signs indicative of neurotoxicity (i.e., ataxia, tremors, fasciculations, prostration, salivation) were observed at 250 mg/kg and above after multiple doses. |
| Supplementary Notes |
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| Availability Notes |
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| Category Codes |
57Y |
| NTIS Prices |
PC A02/MF$25.00 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
019101500 |
| Origin |
NTIS |
| Type |
CAT |
