| Main Title |
Strategies for the Use of Computational SAR Methods in Assessing Genotoxicity. |
| Author |
Richard, A. M. ;
Rabinowitz, J. R. ;
Waters, M. D. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. |
| Publisher |
c1989 |
| Year Published |
1989 |
| Report Number |
EPA/600/J-89/336; |
| Stock Number |
PB90-199464 |
| Additional Subjects |
Computer systems programs ;
Bioassay ;
Computation ;
Reprints ;
Mutagenicity tests ;
Structure-activity relationship ;
Databases
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB90-199464 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
18p |
| Abstract |
The relationship between computational SAR studies and relevant data gathering and generation activities is complex. First, the chemical class to be studied is selected on the basis of information requirements for hazard identification and assessment. Membership in the class is determined by consideration of chemical structure and reactivity. Compilation of the existing bioassay data for this chemical class follows immediately from the specification of the class. Bioassay data, qualitative knowledge of general chemical reactivities in this class, and knowledge concerning potential interactions with biomolecular targets all contribute to the derivation of possible mechanisms for biological activity. Computational studies based on modeling the proposed mechanism of action and/or the existing data base can provide a quantitative basis for the differentiation between chemicals. There is the opportunity for continuing feedback between the quantitative computational studies and the development of a relevant bioassay data base for this chemical class. (Copyright (c) 1989 Elsevier Science Publishers B.V.) |
| Supplementary Notes |
Pub. in Mutation Research, v221 p181-196, 1 Jul 89. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Strategies for the Use of Computational SAR Methods in Assessing Genotoxicity. |
| Category Codes |
57Y |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
016616592 |
| Origin |
NTIS |
| Type |
CAT |
