| Main Title |
Development of a Comparative Potency Method for Cancer Risk Assessment of Complex Mixtures Using Short-Term 'In vivo' and 'In vitro' Bioassays. |
| Author |
Lewtas, J. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1985 |
| Report Number |
EPA/600/J-85/348; |
| Stock Number |
PB86-175437 |
| Additional Subjects |
Bioassay ;
In vivo analysis ;
In vitro analysis ;
Comparison ;
Reprints ;
Carcinogenesis ;
Risk assessment
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB86-175437 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
13p |
| Abstract |
A comparative potency method for cancer risk assessment has been developed based upon a constant relative potency hypothesis. This method was developed and tested using data from a battery of short-term mutagenesis bioassays, animal tumorigenicity data and human lung cancer risk estimations. This data base was developed for a series of complex mixtures including emissions from coke ovens, roofing tar pots, cigarette smoke, and automotive engines. The series of automobiles used in the study included both diesel- and gasoline-powered vehicles. The assumptions inherent in this method are discussed together with the methods and data base used to test these assumptions. |
| Supplementary Notes |
Pub. in Toxicology and Industrial Health, v1 n4 p193-203 1985. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Development of a Comparative Potency Method for Cancer Risk Assessment of Complex Mixtures Using Short-Term 'In vivo' and 'In vitro' Bioassays. |
| PUB Date Free Form |
1985 |
| Category Codes |
6T; 6E; 57Y; 57O |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
614222705 |
| Origin |
NTIS |
| Type |
CAT |
