| Main Title |
Propylene Dichloride: Two-generation Reproduction Study in Sprague-dawley Rats (Final) with Cover Letter. |
| CORP Author |
Dow Chemical Co., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1990 |
| Report Number |
40-9067215 |
| Stock Number |
OTS0527738 |
| Additional Subjects |
Toxicology ;
Health effects ;
1 ;
2-dichloropropane ;
Reproduction/fertility Effects ;
Combined Teratogenicity/reproductive Effects ;
Mammals ;
Rats ;
Oral ;
Toxic substances ;
Laboratory animals ;
CAS No 78-87-5
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0527738 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
168p |
| Abstract |
Propylene dichloride was evaluated for reproductive toxicity in Sprague- Dawley rats (30 rats/sex/generation/concentration group) fed concentrations of 0, 0.024, 0.10, or 0.24% in water through 2 consecutive generations. The high-concentration level represented the maximum attainable concentration based on water solubility. F0 adults were exposed for a 10-week pre-mating treatment period, followed by a 21-day mating period. Following mating, females were treated through gestation, lactation, and weaning. Males continued to be treated post-mating until sacrifice. F1 rats, 21 days of age, were treated for 12 weeks prior to mating. Exposure of F1 animals during mating, gestation, and lactation was similar to that for the F0 animals. Concentration-related palatability effects were observed at all treatment levels in both generations, as indicated by decreases in water consumption and body weight gain during all phases of the study. No treatment related gross pathologic effects were observed. Males and females of both generations at all treatment levels had increased hepatocellular granularity. High- concentration animals of both generations had litters with reduced neonatal body weights and survival rates; the authors considered these effects to be secondary to the substantial decreases in maternal water consumption. The treatment did not adversely affect reproduction at any concentration level. The NOAEL for adults, and NOEL's for neonates and reproduction were 0.024, 0.10, and 0.24%, respectively. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1990 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A09/MF A09 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028802920 |
| Origin |
NTIS |
| Type |
CAT |
