||Evaluation of the C9 Aromatic Hydrocarbons for Mutagenic Potential Bone Marrow Cytogenetics Tests in Rats (Draft) with Cover Letter dated 12/11/87.
||International Research and Development Corp., Mattawan, MI. ;American Petroleum Inst., Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
||16 Dec 1987
Aromatic hydrocarbons ;
Bone marrow ;
Environmental exposure ;
C9 Aromatic hydrocarbons
||Some EPA libraries have a fiche copy filed under the call number shown.
||Four groups of 15 male and 156 female Sprague-Dawley rats were exposed, six hours per day for five consecutive days, to either clean air or 153, 471 or 1,540 ppm of C(sub 9) aromatic hydrocarbon vapor. A fifth group of five males and five females served as positive controls and received an injection of 40 mg/kg cyclophosphamide. Five males and five females from each exposure group were injected with 4 mg/kg colchicine at 6, 24 and 48 hours after the last exposure. Six hours after the colchicine injection, the animals were sacrificed, bone marrow collected, and chromosome spreads prepared. The positive control animals were evaluated at the 24-hour interval. Under the exposure conditions used for this study, C(sub 9) aromatic hydrocarbon vapor did not induce chromosome or chromatid abberations at any exposure level, and therefore, was considered to be non-mutagenic.
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||57Y; 57B; 57F; 68G