| Main Title |
Neurotoxic Effects of Colchicine. |
| Author |
Mundy, W. R. ;
Tilson, H. A. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Publisher |
cApr 90 |
| Year Published |
1990 |
| Report Number |
EPA/600/J-90/325; |
| Stock Number |
PB91-149658 |
| Additional Subjects |
Toxicology ;
Nervous system ;
Colchicine ;
Hippocampus ;
Neurons ;
Axons ;
Mitosis ;
Tubulins ;
Rats ;
Reprints ;
Dentate gyrus
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB91-149658 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
12p |
| Abstract |
Neurotoxicants have found increasing use as tools to study the structure and function of the central nervous system. One class of compounds which block mitosis and disrupt axoplasmic transport includes colchicine, a chemical which is highly toxic to certain neuronal populations. Colchicine administered directly into the hippocampus of rats results in the preferential destruction of dentate gyrus granule cells without affecting the surrounding pyramidal cells. Injection of colchicine into other brain areas also destroys neurons but with less selectivity than is observed in the hippocampus. The neurotoxicity of colchicine appears to be related to the ability to bind to tubulin, although its exact mechanism remains to be elucidated. (Copyright (c) 1990 Intox Press, Inc.) |
| Supplementary Notes |
Pub. in NeuroToxicology (Tradename) 11, p539-548 1990. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Neurotoxic Effects of Colchicine. |
| Category Codes |
57Y; 57S |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
109132251 |
| Origin |
NTIS |
| Type |
CAT |
