| Main Title |
Trimethyltin Effects on Auditory Function and Cochlear Morphology. |
| Author |
Crofton, K. M. ;
Dean, K. F. ;
Menache, M. G. ;
Janssen., R. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;NSI Technology Services Corp., Research Triangle Park, NC. |
| Publisher |
c1990 |
| Year Published |
1990 |
| Report Number |
EPA/600/J-90/236; |
| Stock Number |
PB91-117028 |
| Additional Subjects |
Auditory perception ;
Cochlea ;
Morphology ;
Electrophysiology ;
Behavior ;
Nervous system ;
Rats ;
Reprints ;
Trimethyltin compounds ;
Auditory evoked potentials ;
Startle reaction ;
Dose-response relationships ;
Sensory thresholds
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB91-117028 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
12p |
| Abstract |
TMT is a neurotoxicant known to alter auditory function. The study was designed to compare TMT-induced auditory dysfunction using behavioral, electrophysiological, and anatomical techniques. Adult male Long Evans hooded rats (n=9-12/group) were acutely exposed to saline, 3, 5, or 7 mg/kg TMT. Auditory thresholds were determined 11 weeks post-dosing for 5 and 40 kHz tones using reflex modification of the auditory startle response (ASR). Brainstem auditory evoked response (BAER) thresholds were determined for 5, 40, and 80 kHz tonal stimuli 9 weeks post-dosing. Cochlear histology was assessed at 13 weeks post-dosing. Functional endpoints demonstrated a high-frequency hearing loss. ASR thresholds for 40 kHz tones were elevated 25-35 dB in all dosage groups. BAER thresholds for 40 and 80 kHz tones were elevated 30-50 dB in the 5 and 7 mg/kg groups. Organ of Corti surface preparations revealed a pattern of damage suggesting classical ototoxicity. These data demonstrate the utility of the ASR and BAER in detecting functional alterations in audition and indicate that TMT-induced high-frequency hearing loss is associated with cochlear damage. (Copyright (c) 1990 by Academic Press, Inc.) |
| Supplementary Notes |
Pub. in Toxicology and Pharmacology, v105 n1 p123-132 Aug 90. Presented at the 1989 Annual Meeting of the Society of Toxicology, Atlanta, Georgia. Prepared in cooperation with NSI Technology Services Corp., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Trimethyltin Effects on Auditory Function and Cochlear Morphology. |
| Category Codes |
57Y; 57S; 57A |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
101123838 |
| Origin |
NTIS |
| Type |
CAT |
