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OLS Field Name OLS Field Data
Main Title Drug Transporters [electronic resource] /
Author Fromm, Martin F.
Other Authors
Author Title of a Work
Kim, Richard B.
Publisher Springer Berlin Heidelberg,
Year Published 2011
Call Number RM1-950
ISBN 9783642145414
Subjects Medicine. ; Human physiology. ; Drug interactions. ; Toxicology. ; Pharmaceutical technology. ; Clinical medicine. ; Nephrology.
Internet Access
Description Access URL
Collation X, 454 p. online resource.
Notes Due to license restrictions, this resource is available to EPA employees and authorized contractors only
Contents Notes From the contents -- Preface -- Organic anion transporting polypeptides (OATPs); In vitro and in vivo evidence for the importance of organic anion transporters (OATs) in drug therapy; In vitro and in vivo evidence for the importance of organic cation transporters (OCTs, MATEs) in drug therapy; Intestinal bile salt transporters (ASBT and OST alpha/beta); hepatic bile salt transporters (NTCP and BSEP); Importance of P-glycoprotein for drug-drug interactions; Importance of the multidrug resistance protein (MRP) family for pathophysiology and drug therapy; Importance of breast cancer resistance protein transporters (BCRP); Molecular mechanisms of drug transporters regulation; In vivo probes of drug transport. It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects. This book will give an overview on the transporter families which are most important for drug therapy. Most chapters will focus on one transporter family highlighting tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies.
Place Published Berlin, Heidelberg
Corporate Au Added Ent SpringerLink (Online service)
Title Ser Add Ent Handbook of Experimental Pharmacology, 201
Host Item Entry Springer eBooks
PUB Date Free Form 2011
Series Title Untraced Handbook of Experimental Pharmacology, 201
BIB Level m
Medium computer
Content text
Carrier online resource
Cataloging Source OCLC/T
OCLC Time Stamp 20130725202928
Language eng
OCLC Rec Leader 02979nam a22005535i 45