Main Title |
Acrylamide: a Two-year Drinking Water Chronic Toxicity-oncogenicity Study in Fischer 344 Rats Final Report Sponsored by Amer Cyanamid, dow Chem Usa, Nalco Chem. |
CORP Author |
Dow Chemical Co., Midland, MI. Toxicology Research Lab.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Year Published |
2000 |
Report Number |
40-8431151 |
Stock Number |
OTS0507273 |
Additional Subjects |
Toxicology ;
Health effects ;
Acrylamide ;
Chronic Toxicity ;
Combined Chronic Toxicity/carcinogenicity ;
Mammals ;
Rats ;
Oral ;
Diet ;
Biochemistry ;
Toxic substances ;
Laboratory animals ;
CAS No 79-06-1
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Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
OTS0507273 |
Some EPA libraries have a fiche copy filed under the call number shown. |
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07/26/2022 |
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Collation |
48p |
Abstract |
Acrylamide was tested for chronic toxicity and oncogenicity in Fischer 344 rats (90/sex/dose level) fed nominal doses of 0, 0.01, 0.1, 0.5, or 2.0 mg/kg bw/day in the drinking water for 2 years. In groups given 2.0 mg/kg/day, there was significantly increased mortality (beginning about the 21st month) and degeneration of the peripheral nerves. In females given 2.0 mg/kg/day, tibial nerve degeneration was observed. Other parameters of food and water consumption, clinical chemistry, organ weights, and organ/body weight ratios were not consistently affected by the treatment. A significantly increased tumor incidence at the 2.0 mg/kg/day dose level was reported for the following sites: females; mammary gland (benign and malignant), pituitary gland, central nervous system (malignant), clitoral gland (benign), uterus (malignant), and the oral cavity (benign); males and females; the thyroid gland (malignant and benign). The incidence of scrotal mesothelioma (malignant) was also significantly increased in male rats given 0.5 mg/kg/day. |
Supplementary Notes |
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Availability Notes |
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PUB Date Free Form |
2000 |
Category Codes |
57Y; 57U; 68G; 99; 44G |
NTIS Prices |
PC A04/MF A04 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
028801170 |
Origin |
NTIS |
Type |
CAT |