| Main Title |
Detection of Atypical Cholinesterase by an Automated pH Stat Method, Report of a Family with Both Atypical and Silent Gene Alleles. |
| Author |
Ashby, Thomas M. ;
Suggs, Joseph E. ;
Jue., Danny L. ;
|
| CORP Author |
Environmental Protection Agency, Chamblee, Ga. Office of Pesticides Programs. |
| Year Published |
1970 |
| Stock Number |
PB-275 923 |
| Additional Subjects |
Chemical analysis ;
Cholinesterase ;
Genetics ;
Enzymes ;
Tables(Data) ;
Families ;
Abnormalities ;
Reprints ;
Analytical methods
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB-275 923 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
4p |
| Abstract |
Plasma pseudocholinesterase has no known physiological role but is essential for the rapid degradation of succinylcholine, a muscle relaxant used in surgical procedures. Depression of effective enzyme concentrations as a result of hepatocellular disease or exposure to anticholinesterase agents will increase the patient's sensitivity to succinylcholine and prolong postoperative apnea. Synthesis of this enzyme is controlled by an autosomal gene with multiple variant alleles; individuals phenotypically homozygotic for one of these variants will have either qualitatively 'atypical' pseudocholinesterase with decreased activity or no enzyme at all, and will thus be more sensitive to succinylcholine. The automated pH stat system described here detects atypical cholinesterase by measuring the degree of inhibition of butyrylcholine hydrolysis by dibucaine. |
| Supplementary Notes |
Pub. in Clinical Chemistry, v16 n6 p503-506 1970. |
| Availability Notes |
Included in the report, Journal Articles on Pesticide Biology, PB-275 918. |
| Title Annotations |
Reprint: Detection of Atypical Cholinesterase by an Automated pH Stat Method, Report of a Family with Both Atypical and Silent Gene Alleles, |
| PUB Date Free Form |
8 Apr 70 |
| Category Codes |
6A; 7D; 57D; 99A |
| NTIS Prices |
(Order as PB-275 918, MF A01) |
| Primary Description |
500/01 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
323729934 |
| Origin |
NTIS |
| Type |
CAT |
