| Main Title |
Initial Submission: Inhalation Embryotoxicity Study with Chloroform in Wistar Rats with Cover Letter dated 07/24/92. |
| CORP Author |
Hoechst Celanese Corp., Summit, NJ.; Dow Corning Corp., Hemlock, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1992 |
| Report Number |
88-920005781 |
| Stock Number |
OTS0544564 |
| Additional Subjects |
Toxicology ;
Health effects ;
Chloroform ;
Reproduction/fertility Effects ;
Teratogenicity ;
Mammals ;
Rats ;
Inhalation ;
Toxic substances ;
Laboratory animals ;
CAS No 67-66-3
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0544564 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
68p |
| Abstract |
Chloroform (CAS No. 67-66-3) was evaluated for developmental toxicity in 4 groups of 20 presumed-pregnant Wistar rats exposed by inhalation to nominal concentrations of 0, 30, 100, or 300 ppm for 7 hours/day, on days 7 to 16 of gestation. Dams were sacrificed on gd 21. Maternal effects were limited to concentration-related decreases in feed consumption and body weight gain. Death of all embryonic primordia occurred in 2/20, 3/20, and 8/20 dams in the 30, 100, and 300 ppm groups, respectively. None of the control dams showed 100% mortality of embryos. All remaining treated dams showed 'slightly' stunted fetuses. However, no gross external, visceral, or skeletal anomalies were observed. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Dow Corning Corp., Hemlock, MI. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1992 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A05/MF A05 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028803620 |
| Origin |
NTIS |
| Type |
CAT |
