| Main Title |
Kinetics and Metabolism of Inhaled Methyl Chloroform (1,1,1-Trichloroethan) in Human Volunteers with Cover Letter. |
| CORP Author |
Dow Chemical Co., Midland, MI.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
28 Jun 1983 |
| Year Published |
1983 |
| Report Number |
OTS-878213685; |
| Stock Number |
OTS-0206356 |
| Additional Subjects |
Kinetics ;
Metabolism ;
Inhalation ;
Chloroform ;
Humans ;
Males ;
Lungs ;
Exposure ;
Toxicity ;
Blood ;
Air ;
Rats ;
Methyl chloroform(MC) ;
Trichloroethanol(TCE) ;
Trichloroacetic acid(TCA) ;
1,1,1,-Trichloroethane
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0206356 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
32p |
| Abstract |
The kinetics of inhaled methyl chloroform (MC) and its principal metabolites, trichloroethanol (TCE) and Trichloroacetic acid (TCA), were defined in 6 healthy male volunteers following single 6 hr exposures of 350 and 35 ppm. Blood and expired air MC concentrations were proportional to the exposure concentration and indicated about 25% of the MC inhaled during the 6 hr exposure was absorbed. Elimination of MC was tri-exponential with half-lives estimated as 44 min, 5.7. hr and 53 hr for the initial, intermediate and terminal phases. Over 91% of the absorbed MC was excreted unchanged via the lungs, 5-6% was metabolized and excreted as TCE and TCA, and less than 1% remained in the body after 9 days. Urinary TCE and TCA excretion were extremely variable and indicated that urinary TCE and TCA measurements provide at best only a rough estimate of the exposure. These data suggest that the kinetics of MC in man is essentially first-order at or below the current TLV of 350 ppm. Based on a comparison of the blood MC levels and amounts of MC metabolized, the rat is a better model than the mouse to predict the toxicity of MC in man. |
| Supplementary Notes |
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| Availability Notes |
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| Category Codes |
57Y; 57O |
| NTIS Prices |
PC A04/MF A01 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
009401080 |
| Origin |
NTIS |
| Type |
CAT |
