Main Title |
Review of a Draft Health Assessment Document for Polychlorinated Debenzofurans. |
CORP Author |
Environmental Protection Agency, Washington, DC. Science Advisory Board. |
Year Published |
1987 |
Report Number |
SAB/EHC-87/021; |
Stock Number |
PB88-245535 |
Additional Subjects |
Chlorine organic compounds ;
Carginogens ;
Evaluation ;
Toxic substances ;
Polychlorinated dibenzofurans ;
Health effects ;
Risk assessment ;
Polychlorinated dibenzodioxins ;
Teratogens ;
Receptors
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB88-245535 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
7p |
Abstract |
The available information on polychlorinated dibenzofurans is scant. For this reason, staff utilized information about polychlorinated dibenzo-p-dioxins in the assessment. The scientific theory that supports the use of the analogy is sound. Both groups of substances are thought to cause biological effects by binding with different affinities to the same intracellular receptor molecule. However, the draft document assumes the theory for one plausible effect of receptor binding, namely developmental abnormalities, and not for other effects which have been attributed to polychlorinated dibenzo-p-dioxins in previous Agency assessments, such as carcinogenicity. The Subcommittee requests that EPA either assume the same theory for all effects or provide an explanation of why carcinogenic effects do not follow from binding to the receptor. |
NTIS Title Notes |
Final rept. |
PUB Date Free Form |
16 Jan 87 |
Category Codes |
57Y; 68G |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
100/00 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
830230654 |
Origin |
NTIS |
Type |
CAT |