| Main Title |
Chemical Reactivity, Cytotoxicity, and Mutagenicity of Chloropropanones. |
| Author |
Merrick, B. A. ;
Smallwood, C. L. ;
Meier, J. R. ;
McKean, D. L. ;
Kaylor, W. H. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1987 |
| Report Number |
EPA/600/J-87/277; |
| Stock Number |
PB88-185525 |
| Additional Subjects |
Chemical reactions ;
Toxicity ;
Chlorine organic compounds ;
Rats ;
Water treatment ;
Laboratory animals ;
In vitro analysis ;
Cytology ;
Disinfection ;
Mutagens ;
Carcinogens ;
Chlorination ;
Disinfection ;
Salmonella ;
Biodeterioration ;
Humans ;
Exposure ;
Concentration(Composition) ;
pH ;
Metabolism ;
Reprints ;
Chloropropanones ;
Haloketones ;
Propanone/dichloro ;
Propanone/monochloro
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB88-185525 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
11p |
| Abstract |
Studies were conducted to assess the in vitro toxicity of three chloropropanones: monochloropropanone (MCP), 1,1-dichloropropanone (1,1-DCP) and 1,3-dichloropropanone (1,3-DCP). Chloropropanones reacted directly with reduced glutathione in sodium phosphate buffer at pH 7.4. All chloropropanones were cytotoxic to suspensions of male, rat hepatocytes in a concentration range of 0.5-10 mM. Cytotoxicity was preceded by rapid decline in cellular GSH levels. Mutagenic potencies among the chloropropanes in Salmonella typhimurium bacteria differed greatly. 1,3-DCP was mutagenic in the nmole range, 1,1-DCP was weakly mutagenic in the micromole range and MCP was not mutagenic. Mutagenicity of the dichloropropanones was evident without metabolic activation. |
| Supplementary Notes |
Pub. in Toxicology and Applied Pharmacology 91, n1 p46-54 1987. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Chemical Reactivity, Cytotoxicity, and Mutagenicity of Chloropropanones. |
| PUB Date Free Form |
1987 |
| Category Codes |
50B; 68D; 57; 99A |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
814621236 |
| Origin |
NTIS |
| Type |
CAT |
