| Main Title |
Acute Toxicity Studies in Rats and Rabbits with Cover Letter. |
| CORP Author |
International Research and Development Corp., Mattawan, MI. ;Olin Corp., New Haven, CT.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
24 Nov 1982 |
| Year Published |
1982 |
| Report Number |
878210870; |
| Stock Number |
OTS-0205877 |
| Additional Subjects |
Toxicity ;
Laboratory animals ;
Alkylating agents ;
Oral dosage ;
Rats ;
Rabbits ;
Dermal absorption ;
Eye ;
Irritation ;
Response(Biology) ;
Mortality ;
Chemical compounds ;
Body weight ;
Alkyl epoxides ;
Oilin Corporation
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0205877 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
88p |
| Abstract |
The acute oral LD50 of Olin-35836 in the albino rat was found to be 3160 mg. /kg. Confidence could not be calculated because of the all-or-none response exhibited by the groups of rats administered the test material. Olin-53836 did not produce any evidence of dermal irritation or toxicity in the rabbits to which the test material was applied in dosages as high as 2000 mg. /kg. Instillation of Olin-53836 into the unwashed eyes of albino rabbits produced severe irritation including purulent discharge, pannus and opacity of the cornea. These signs were still in evidence at the end of 7 days of observation. However, those rabbits in which the eyes were irrigated 2 and 4 seconds after instillation of the test material, only slight irritation to the conjunctivae was noted which disappeared within 4 days after treatment. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with American Petroleum Inst., Washington, DC. |
| Availability Notes |
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| Category Codes |
57Y; 57O |
| NTIS Prices |
PC A06/MF A01 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
009400800 |
| Origin |
NTIS |
| Type |
CAT |
