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OLS Field Name OLS Field Data
Main Title Effects of tributyltin on biomembranes : alteration of flow cytometric parameters and inhibition of Na(+)K(+)-ATPase two-dimensional crystallization /
Author Massaro, E. J. ; Zucker, R. M. ; Elstein, K. H. ; Easterling, R. E. ; Ting-Beall, H. P. ; Allis, J. W.
Other Authors
Author Title of a Work
Zucker, R. M.
Elstein, K. H.
Easterling, R. E.
Ting-Beall, H. P.
Allis, J. W.
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC. ;Duke Univ. Medical Center, Durham, NC.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,
Year Published 1988
Report Number EPA/600/D-89/019
Stock Number PB89-218192
Subjects Risk assessment.
Additional Subjects Toxicity ; Fluorescein ; Crystallization ; Fluorescence ; Exposure ; Cell nucleus ; Hydrolysis ; Membranes(Biology) ; Tributyltin ; Environmental pollution ; Flow cytometry ; Sodium potassium ATPASE ; Enzyme inhibitors ; Cultured tumor cells
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB89-218192 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 01/01/1988
Collation 14 pages ; 28 cm
Abstract The cell interacts with its environment via the plasma membrane. Alteration of the composition/structure of this membrane can result in altered cell function. Therefore, the ability to detect subtle changes in the condition of the membrane may be of considerable value in predicting the response of cells to toxic insult. Tributyltin is a membrane-active toxicant of considerable environmental concern since it is extensively employed as a component of marine antifouling paints. Its effect on the murine erythroleukemic cell by flow cytometry has been investigated and has been observed to be toxic at extremely low levels (micromolar concentrations). These data have been utilized recently by the state of Virginia to lower their saltwater standard for this chemical.
Notes "Presented at the Proceedings of Hanford Life Sciences Symposium, Richland Washington (10/18-20/88) and submitted to Toxicology and Applied Pharmacology, vol. 96, pp. 393-403, 1988." EPA/600/D-89/019. PB89-218192. Includes bibliographical references. Microfiche.
Place Published Research Triangle Park, NC :
Supplementary Notes Pub. in Toxicology and Applied Pharmacology, v96 p393-403, 1988. Proceedings of Hanford Life Sciences Symposium, Richland, WA., October 18-20, 1988. Prepared in cooperation with Northrop Services, Inc., Research Triangle Park, NC., and Duke Univ. Medical Center, Durham, NC.
Corporate Au Added Ent United States. Environmental Protection Agency. Office of Research and Development. ; Health Effects Research Laboratory. ; Northrop Services.
PUB Date Free Form {1988}
NTIS Prices PC A03/MF A01
BIB Level m
Cataloging Source OCLC/T
OCLC Time Stamp 20000825190123
Language eng
Origin NTIS
Type MERGE
OCLC Rec Leader 01680nam 2200361Ka 45020