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Main Title Analysis of the Genotoxicity of Nine Acrylate/Methacrylate Compounds in L5178Y Mouse Lymphoma Cells.
Author Dearfield, K. L. ; Millis, C. S. ; Harrington-Brock, K. ; Doerr, C. L. ; Moore, M. M. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Environmental Health Research and Testing, Inc., Durham, NC.
Publisher c1989
Year Published 1989
Report Number EPA/600/J-89/227;
Stock Number PB90-146036
Additional Subjects Toxicity ; Lymphomas ; Acrylates ; Methacrylates ; Tables(Data) ; Graph(Charts) ; Mice ; Mutations ; Cell nucleus ; Esters ; Reprints ; Mutagenicity tests ; Dose-response relationships ; Risk assessment ; Cultured cells
Library Call Number Additional Info Location Last
NTIS  PB90-146036 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 15p
Abstract Nine acrylate/methacrylate esters were tested for the induction of mutations, aberrations, and micronuclei in cultured L5178Y mouse lymphoma cells without exogenous activation. With the exception of 2-ethylhexyl acrylate, and dicyclopentenyloxyethyl methacrylate which produced equivocal responses, the other seven compounds (2-hydroxyethyl acrylate, dicyclopentenyloxyethyl acrylate, tetraethylene glycol diacrylate, tetraethylene glycol dimethacrylate, trimethylolpropane triacrylate, trimethylolpropane trimethacrylate, and pentaerythritol triacrylate) produced positive genotoxic responses with different potencies. Primarily small-colony, TFT-resistant mutants were induced, suggesting a clastogenic mechanism that was supported by increased aberration and micronucleus frequencies. Generally, it was found that multifunctional compounds (esters with more than 1 functional vinyl group) required lower concentrations than monofunctional compounds to induce maximal cytotoxic, mutagenic, and clastogenic responses. In addition, acrylates were generally more potent than their corresponding methacrylates.
Supplementary Notes Pub. in Mutagenesis, v4 n5 p381-393 1989. Prepared in cooperation with Environmental Health Research and Testing, Inc., Durham, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Analysis of the Genotoxicity of Nine Acrylate/Methacrylate Compounds in L5178Y Mouse Lymphoma Cells.
Category Codes 57Y; 57F
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 007530399
Origin NTIS
Type CAT