||Analysis of the Genotoxicity of Nine Acrylate/Methacrylate Compounds in L5178Y Mouse Lymphoma Cells.
Dearfield, K. L. ;
Millis, C. S. ;
Harrington-Brock, K. ;
Doerr, C. L. ;
Moore, M. M. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Environmental Health Research and Testing, Inc., Durham, NC.
Cell nucleus ;
Mutagenicity tests ;
Dose-response relationships ;
Risk assessment ;
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||Nine acrylate/methacrylate esters were tested for the induction of mutations, aberrations, and micronuclei in cultured L5178Y mouse lymphoma cells without exogenous activation. With the exception of 2-ethylhexyl acrylate, and dicyclopentenyloxyethyl methacrylate which produced equivocal responses, the other seven compounds (2-hydroxyethyl acrylate, dicyclopentenyloxyethyl acrylate, tetraethylene glycol diacrylate, tetraethylene glycol dimethacrylate, trimethylolpropane triacrylate, trimethylolpropane trimethacrylate, and pentaerythritol triacrylate) produced positive genotoxic responses with different potencies. Primarily small-colony, TFT-resistant mutants were induced, suggesting a clastogenic mechanism that was supported by increased aberration and micronucleus frequencies. Generally, it was found that multifunctional compounds (esters with more than 1 functional vinyl group) required lower concentrations than monofunctional compounds to induce maximal cytotoxic, mutagenic, and clastogenic responses. In addition, acrylates were generally more potent than their corresponding methacrylates.
||Pub. in Mutagenesis, v4 n5 p381-393 1989. Prepared in cooperation with Environmental Health Research and Testing, Inc., Durham, NC.
|NTIS Title Notes
||Reprint: Analysis of the Genotoxicity of Nine Acrylate/Methacrylate Compounds in L5178Y Mouse Lymphoma Cells.
||PC A03/MF A01