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Main Title Sensitivity of Sertoli and Leydig Cells to Xenobiotics in in Vitro Models.
Author Steinberger, A. ; Klinefelter, G. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Reproductive Toxicology Branch. ;Texas Univ. Medical School at Houston. Dept. of Obstetrics, Gynecology and Reproductive Sciences.
Publisher 1993
Year Published 1993
Report Number EPA/600/J-94/034;
Stock Number PB94-137205
Additional Subjects Sertoli cells ; Leydig cells ; Xenobiotics ; Toxicology ; In vitro analysis ; Cultured cells ; Reproduction(Biology) ; Meiosis ; Cell differentiation ; Testis ; Phthalates ; Cadmium halides ; Biological models ; Reprints ;
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NTIS  PB94-137205 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 15p
Abstract Today we realize that by elucidating the underlying toxicological mechanisms of toxicant action, we can greatly improve our ability to accurately assess human risk. After adequate dose-response and target organ data are gained from in vivo toxicant exposures, validated in vitro models are appropriate to study the sequelae of subcellular effects elicited by the toxicant. In many cases of spermatogenic dysfunction Sertoli and/or Leydig cell compromise is indicated. We describe herein the current in vitro models for examining Sertoli and Leydig cell function during xenobiotic exposure. These methods have already served to shed much light on the mechanism of action of ethane dimethanesulphonate, a well known Leydig cell toxicant, and the phthalates which are cytotoxic to Sertoli cells. Future research utilizing these in vitro models will undoubtedly lead to an awareness of homologous mechanisms of toxicant action between rodents and humans, knowledge which will ultimately be used to develop biomarkers for effects.
Supplementary Notes Pub. in Reproductive Toxicology, v7 supl p23-37 Aug 93. Prepared in cooperation with Texas Univ. Medical School at Houston. Dept. of Obstetrics, Gynecology and Reproductive Sciences.
NTIS Title Notes Journal article.
Title Annotations Reprint: Sensitivity of Sertoli and Leydig Cells to Xenobiotics in in Vitro Models.
Category Codes 57Y; 57F
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 409118388
Origin NTIS
Type CAT