| Main Title |
Triphenyl Phosphite-Induced Ultrastructural Changes in Bovine Adrenomedullary Chromaffin Cells. |
| Author |
Anderson, J. K. ;
Veronesi, B. ;
Jones, K. ;
Lapadula, D. M. ;
Abou-Donia, M. B. ;
|
| CORP Author |
Duke Univ. Medical Center, Durham, NC.;Environmental Protection Agency, Research Triangle Park, NC. Neurotoxicology Div. |
| Publisher |
c1992 |
| Year Published |
1992 |
| Report Number |
EPA/600/J-92/271; |
| Stock Number |
PB92-209337 |
| Additional Subjects |
Adrenal medulla ;
Chromaffin granules ;
Toxicology ;
Cultured cells ;
Cattle ;
Electron microscopy ;
Paraoxon ;
Isoflurophate ;
Nervous system ;
Adenosine ;
Adenosine triphosphate ;
Reprints ;
Triphenyl phosphite
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB92-209337 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
12p |
| Abstract |
Primary cultures of bovine adrenomedullary chromaffin cells were treated with the phosphorous acid ester, triphenyl phosphite (TPP), and the morphological changes assessed by transmission electron and scanning microscopy. Parallel studies were carried out with the cholinergic compound 0,0-diethyl-4 nitrophenyl phosphate (paraoxon) and the delayed neurotoxicant 0,0-diisopropylphosphorofluoridate (DFP). Transmission and scanning electron microscopy revealed that treatment with both of these organophosphorous compounds did not produce the ultrastructural effects that were seen with TPP. Treatment with 100 micromoles TPP for 4 or 24 hours caused a marked inhibition (90% relative to controls) of adenosine incorporation. Neither 100 micromoles paraoxon or 100 micromoles DFP had an inhibitory effect on incorporation. The results support a specific affect of the triphenylphosphite, TPP, not a general toxic effect of organophosphorous compounds since the cholinergic agent paraoxon and the delayed neurotoxic compound DFP did not alter the cells ultrastructure. |
| Supplementary Notes |
Pub. in Toxicology and Applied Pharmacology, v112 n1 Jan 92. Sponsored by Environmental Protection Agency, Research Triangle Park, NC. Neurotoxicology Div. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Triphenyl Phosphite-Induced Ultrastructural Changes in Bovine Adrenomedullary Chromaffin Cells. |
| Category Codes |
57Y; 57F |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
225526106 |
| Origin |
NTIS |
| Type |
CAT |
