| Main Title |
Metabolism, Toxicity, and Carcinogenicity of Trichloroethylene. |
| Author |
Bruckner, J. V. ;
Davis, B. D. ;
Blancato, J. N. ;
|
| CORP Author |
Environmental Monitoring Systems Lab., Las Vegas, NV. ;CH2M/Hill, Reston, VA. ;Georgia Univ., Athens. Dept. of Pharmacology and Toxicology. |
| Publisher |
c1989 |
| Year Published |
1989 |
| Report Number |
EPA/600/J-89/321; |
| Stock Number |
PB90-198631 |
| Additional Subjects |
Toxicity ;
Metabolism ;
Vinyl chloride ;
Kidney ;
Liver ;
Laboratory animals ;
Reprints ;
Carcinogenicity tests ;
Pharmacokinetics ;
Dose-response relationships
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB90-198631 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
22p |
| Abstract |
Lifetime cancer or unit risk estimates for trichloroethylene (TRI) have been calculated on the basis of metabolized dose-tumor incidence relationships. Previously, it was common practice to directly extrapolate exposure dose-tumor incidence data from laboratory animal studies to predict cancer risks in humans. Such direct species-to-species extrapolations, however, do not take into account potentially important species differences in pharmacokinetics. The consideration and use of pharmacokinetics and metabolic data can significantly reduce, though not eliminate, uncertainties inherent in species-to-species, route-to-route, and high- to low-dose extrapolations. The total amount of TRI metabolized was considered in the most recent EPA Health Assessment Document for Trichloroethylene to be the effective dose (EFD) produced tumors. |
| Supplementary Notes |
Pub. in Critical Reviews in Toxicology, v20 n1 p31-50 1989. Prepared in cooperation with CH2M/Hill, Reston, VA., and Georgia Univ., Athens. Dept. of Pharmacology and Toxicology. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Metabolism, Toxicity, and Carcinogenicity of Trichloroethylene. |
| Category Codes |
57Y; 57B |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/07 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
014419676 |
| Origin |
NTIS |
| Type |
CAT |
