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Main Title 1,2-Dibromoethane Causes Rat Hepatic DNA Damage at Low Doses.
Author Kitchin, K. T. ; Brown, J. L. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1986
Report Number EPA/600/J-86/349;
Stock Number PB87-184685
Additional Subjects Dosage ; Toxicity ; Liver diseases ; Solvents ; Genetics ; Rats ; Carcinogens ; Alpha amino carboxylic acids ; Glutathione ; Cytochromes ; Reprints ; Dibromoethane ; Halogenated hydrocarbons ; Mutagens ; SGPT(Serum Alanine Transaminase)
Library Call Number Additional Info Location Last
NTIS  PB87-184685 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
Abstract Two oral administrations of 1,2-dibromoethane to adult female rats at doses above 10 micromoles/kg (1.9 mg/kg) caused DNA damage as determined by the alkaline elution technique. Far greater doses (300 micromoles/kg, 56.4 mg/kg) of 1,2-dibromoethane were required to cause other hepatic biochemical effects, such as increased activity of ornithine decarboxylase. In the dose range of 10-300 micromoles/kg, no increase in the activity of serum enzyme alanine transaminase (SGPT) was observed. Of the six organs studied, liver showed the largest amount of DNA damage. Thus, the carcinogen 1,2-dibromoethane caused substantial DNA damage at doses far below those required to show other biochemical effects or frank liver toxicity.
Supplementary Notes Pub. in Biochemical and Biophysical Research Communications, v141 n2 p723-727A, 15 Dec 86.
NTIS Title Notes Journal article.
Title Annotations Reprint: 1,2-Dibromoethane Causes Rat Hepatic DNA Damage at Low Doses.
PUB Date Free Form 1986
Category Codes 68G; 57F; 57O; 57Y
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 718323445
Origin NTIS
Type CAT