| Main Title |
Oral Toxicity of Carbon Tetrachloride: Acute, Subacute, and Subchronic Studies in Rats. |
| Author |
Bruckner, J. V. ;
MacKenzie, W. F. ;
Muralidhara, S. ;
Luthra, R. ;
Kyle, G. M. ;
|
| CORP Author |
Georgia Univ., Athens. Dept. of Pharmacology and Toxicology. ;Texas Univ. Medical School at Houston. ;Texas Univ. at Austin.;Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1986 |
| Report Number |
EPA/600/J-86/008; |
| Stock Number |
PB86-176153 |
| Additional Subjects |
Carbon tetrachloride ;
Toxicology ;
Liver ;
Biochemistry ;
Metabolism ;
Ingestion(Biology) ;
Rats ;
Laboratory animals ;
Dosage ;
Reprints ;
Liver function
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB86-176153 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
21p |
| Abstract |
The investigation was conducted to characterize the acute, subacute and subchronic toxic potency of ingested carbon tetrachloride (CCl4). In the first acute and subchronic toxicity study, male Sprague-Dawley rats of 300-350 g were gavaged with 0, 20, 40 or 80 mg CCl4/kg once daily for 5 consecutive days, rested for 2 days, and dosed once daily for 4 additional days. Rats of 200-250 g were gavaged with 0, 20, 80 or 160 mg CCl4/kg according to the same dosage regimen in the second acute and subacute study. In the first and second studies one group of rats at each dosage-level was sacrificed for clinical chemistry and histopathological evaluation at 24 hr, 4 days and 11 days after initiation of dosing. Single 20 and 40 mg/kg doses had no apparent toxic effect at 24 hr, though 80 mg/kg caused mild hepatic centrilobular vacuolization and significant increases in some serum enzyme levels. In general, there was progressively severe hepatic injury at each dosage-level over the 11-day period. |
| Supplementary Notes |
Pub. in Fundamental and Applied Toxicology 6, p16-34 Jan 86. Prepared in cooperation with Texas Univ. Medical School at Houston, and Texas Univ. at Austin. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Oral Toxicity of Carbon Tetrachloride: Acute, Subacute, and Subchronic Studies in Rats. |
| PUB Date Free Form |
c1986 |
| Category Codes |
6T; 6A; 57Y; 57B |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
614223036 |
| Origin |
NTIS |
| Type |
CAT |
