||Activity Profiles of Developmental Toxicity: Design Considerations and Pilot Implementation.
Kavlock, R. J. ;
Greene, J. A. ;
Kimmel, G. L. ;
Morrissey, R. E. ;
Owens, E. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Burroughs Wellcome Co., Research Triangle Park, NC. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC. ;Chemical Industry Inst. of Toxicology, Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill.
Dose-response relationships ;
Structure-activity relationships ;
Data bases ;
Mutagenicity tests ;
||Some EPA libraries have a fiche copy filed under the call number shown.
||The available literature was searched for quantitative test results from both in vitro and in vivo assays for developmental toxicity for five model compounds: cyclophosphamide, methotrexate, hydroxyurea, caffeine, and ethylenethiourea. Nine cellular-based assays, six assays using whole embryos in culture, as well as Segment II and abbreviated exposure tests for mammalian test species are included in the database. For each assay, the critical endpoints were identified, each of which was then provided a three-letter code, and the criteria for extraction of quantitative information were established. The extracted information was placed into a computerized reference file and subsequently plotted such that the qualitative (positive/negative) and quantitative (e.g., IC(sub 50), highest ineffective dose (HID), lowest effective dose (LED)) results across all test systems could be displayed. The information contained in these profiles can be used to compare qualitative and quantitative results across multiple assay systems, to identify data gaps in the literature, to evaluate the concordance of the assays, to calculate relative potencies, and to examine structure-activity relationships.
||Pub. in Teratology, v43 n2 p159-185 Feb 91. Prepared in cooperation with Burroughs Wellcome Co., Research Triangle Park, NC., Environmental Health Research and Testing, Inc., Research Triangle Park, NC., Chemical Industry Inst. of Toxicology, Research Triangle Park, NC., and North Carolina Univ. at Chapel Hill.
|NTIS Title Notes
||Reprint: Activity Profiles of Developmental Toxicity: Design Considerations and Pilot Implementation.
||PC A03/MF A01