| Main Title |
Effects of Cadmium Exposure on Rat Kidneys. |
| Author |
King, Leon C. ;
Clark, Vernon ;
Faeder., Edward J. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, N.C. Environmental Toxicology Div.;North Carolina Central Univ., Durham. Dept. of Biology. |
| Year Published |
1976 |
| Report Number |
EPA/600/J-76-077; |
| Stock Number |
PB-278 616 |
| Additional Subjects |
Cadmium ;
Toxicity ;
Kidney ;
Rats ;
Laboratory animals ;
Bioassay ;
Dosage ;
Kidney functioning tests ;
Enzymes ;
Metals ;
Nitrogen organic compounds ;
Toxicology ;
Reprints ;
Transpeptidases/glutamyl
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB-278 616 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
8p |
| Abstract |
The objectives of this investigation were to study the effects of cadmium toxicity on the kidney at chronic and acute dosing and to determine whether there is a release of the tubular enzyme glutamyl transpeptidase (GT) into the urine. The dosing regimen was established in such a way that after four weeks, the low chronic group had received about the same total amount of cadmium as the low acute group, and the high chronic group received about the same total amount of cadmium as the high acute group. Kidney cadmium concentrations in the acutely dosed animals reached higher levels than in the corresponding chronically dosed groups. Zinc levels remained essentially the same for all dosed groups. Cadmium levels in urine, for all groups, throughout the experiment, were less than 0.05 microgram/ml. Both acutely dosed groups gained substantially less weight than the chronically dosed groups. Acutely exposed animals showed greatly depressed urinary protein excretion for all days measured. Chronically exposed animals showed essentially the same protein excretion as control animals. Urinary GT levels were significantly decreased in acutely dosed animals from day 3 to 21. Chronically dosed animals also showed diminished GT levels after day 7. |
| Supplementary Notes |
Prepared in cooperation with North Carolina Central Univ., Durham. Dept. of Biology. |
| Availability Notes |
Pub. in Bulletin of Environmental Contamination and Toxicology, v16 n5 p572-577 1976. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Effects of Cadmium Exposure on Rat Kidneys. |
| PUB Date Free Form |
1976 |
| Category Codes |
6T; 6F; 57Y; 68G; 57H |
| NTIS Prices |
Not available NTIS |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
323737088 |
| Origin |
NTIS |
| Type |
CAT |
