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Main Title Acute Inhalation Toxicity Study of Parachlorobenzotrifluoride in the Rat.
CORP Author Bio-Dynamics Research and Development Corp., Eugene, OR.; Hooker Chemical Corp., Burlington, NJ.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 2000
Report Number 40-7952011
Stock Number OTS0508137
Additional Subjects Toxicology ; Health effects ; 4-chlorobenzotrifluoride ; Acute Toxicity ; Mammals ; Rats ; Inhalation ; Toxic substances ; Laboratory animals ; CAS No 98-56-6
Library Call Number Additional Info Location Last
NTIS  OTS0508137 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 18p
Abstract Acute inhalation toxicity was evaluated in groups of 10 Sprague-Dawley rats (5 male and 5 female) exposed to parachlorobenzotrifluoride at nominal concentrations of 6.03, 20.8, 28.4, 39.1, or 66.7 mg/l for 4 hours. Mortality was observed in 4 animals in the 28.4 mg/l dose group, in 6 animals in the 39.1 mg/l dose group, and in 8 animals in the 66.7 mg/l dose group. The LC50 value was determined to be 33.0 mg/l (95% confidence limits of 22.2 to 49.2 mg/l) for a 4 hour exposure period. Clinical observations during exposure included: redness around eyes; muscle spasms; labored breathing; reduction in activity or prostration; excessive salivation and lacrimation; mucoid nasal discharge; and partially closed eyes. Clinical observations made in the 14 day post exposure period included: red and mucoid nasal discharge; soft stool; labored breathing; excessive lacrimation; hypersensitivity to sound; increased activity; dry rales; yellow staining of the ano-genital region; aggressive behavior; poor condition; uncoordinated movement; limb ataxia; partially closed eyes; alopecia; hair loss; rapid breathing; red penis discharge; and chromodacryorrhea. Observations on gross necropsy of decedents and animals surviving to the end of the 14 day observation period included: lung discoloration; enlarged lungs; dark red foci in lungs; liver discoloration (in animals dying spontaneously); gas filled stomach and intestines; and kidney discoloration.
Supplementary Notes The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Hooker Chemical Corp., Burlington, NJ.
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PUB Date Free Form 2000
Category Codes 57Y; 57U; 68G; 99; 44G
NTIS Prices PC A03/MF A03
Document Type NT
Cataloging Source NTIS/MT
Control Number 028801260
Origin NTIS
Type CAT