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Main Title Acute Toxicity Studies in Rabbits and Rats with Hexabromocyclododecane with Attachments.
CORP Author Velsicol Chemical Corp., Chicago, IL.; International Research and Development Corp., Mattawan, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1978
Report Number 8EHQ-0278-0065
Stock Number OTS0200051
Additional Subjects Toxicology ; Health effects ; Hexabromocyclododecane ; Primary eye irritation ; Mammals ; Rabbits ; Dermal ; Primary dermal irritation ; Acute toxicity ; Rats ; Oral ; Gavage ; Inhalation ; CAS No 77-47-4
Library Call Number Additional Info Location Last
NTIS  OTS0200051 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 91p
Abstract Hexabromocyclododecane was assessed for primary eye irritation with New Zealand White rabbits (3/sex) administered 100 mg of test material in the conjunctival sac of the right eye. Treated unwashed eyes were examined at 24, 48, and 72 hours, and at 7 days. Eye irritation scores derived by the Draize method were indicative of no irritation. A primary skin irritation study was conducted with similar groups of rabbits exposed to 500 mg of test material applied to the back of each rabbit and occluded for 4 hours. Test sites were then washed and examined for irritation at 4, 24, 48, and 72 hours. No evidence was seen of primary skin irritation (mean score = 0.1). Acute dermal toxicity was assayed with rabbits (2/sex) administered doses of 20,000 mg/kg to abraded and intact dorsal skin. Test sites were occluded for 24 hours, then uncovered and washed with tap water. Observation for 14 days revealed no mortalities, but body weight gain was decreased and diarrhea was noted in 1 treated rabbit/sex. Charles River CD strain rats (5/sex) were administered oral doses of 10,000 mg/kg of test material suspended in corn oil by gavage (volume = 20 ml/kg bw) and observed for 14 days. No deaths occurred. Corneal opacity and ptosis were seen in males; diarrhea and hypoactivity were noted in females. Charles River CD rats (3/sex) were exposed to 202.14 mg/L of the test material as dust over a 4 hour exposure period. Slight dyspnea was noted during the exposure period, but no other adverse effects were seen.
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PUB Date Free Form Feb 1978
Category Codes 57Y; 57U; 68G; 99; 48G
NTIS Prices PC A06/MF A06
Document Type NT
Cataloging Source NTIS/MT
Control Number 010500440
Origin NTIS
Type CAT