||Acute Oral Toxicity to Rats of Hexachlorocyclopentadiene with Cover Letter 11/25/1986.
||Huntingdon Research Centre PLC (England).; Velsicol Chemical Corp., Chicago, IL.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Hexachlorocyclopentadiene (77-47-4) ;
Acute Toxicity ;
Toxic substances ;
Laboratory animals ;
CAS No 77-47-4
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||Acute oral toxicity was evaluated in groups of 5 male and 5 female Sprague-Dawley rats administered hexachlorocyclopentadiene in corn oil by gavage at a level of 1.26, 1.60 or 2.00 g/kg. Mortality was observed in 1 male and 2 females in the 1.26 g/kg group, 3 males and 5 females in the 1.60 g/kg group and in all animals in the 2.00 g/kg group. The LD50 was determined to be 1.4 (1.2-1.5) g/kg for males and females combined, 1.5 (1.3-1.7) g/kg for males only and 1.3 (1.0-1.5) g/kg for females only. Clinical observations included piloerection, abnormal posture and gait, lethargy, decreased respiration, ptosis, pallor of the extremities, diarrhea and prostration. Necropsy revealed nothing unusual.
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||57Y; 57U; 68G; 99; 44G
||PC A03/MF A03