||Initial Submission: Letter from Confidential Source to USEPA Reporting Neurotoxicity in Acute Inhalation Toxicity Study in Rats of Cyclopropanecarboxylic Acid, 3-(2-chloro-3, 3,3-trifluoro-1- propenyl)-2,2-dimethyl cyano(3-phenoxyphenyl)methyl ester,(1R-(1.alpha.(s(asterick), 3.alpha.(Z)))) dated 12/14/99. (Sanitized).
||; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Acute toxicity ;
Laboratory animals ;
Test methods ;
Toxic substances ;
Cyclopropanecarboxylic acid ;
CAS No 76703-62-3 ;
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||Groups of 5 male and 5 female Wistar Han rats were administered the test material by inhalation for four hours to a time-weighted average chamber concentration of 35.1 mg/m3 and were observed for 14 days. Three males and two females survived the observation period. Neurologic toxicity was observed in all surviving animals. Observations included incoordination, inability to walk and one female had tremors.
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|PUB Date Free Form
||20 Dec 1999
||57Y; 57U; 68G; 99
||PC A01/MF A01