||Results of Skin and Eye Irritation Studies on Chlorothene (Old Formulation) and Chlorothene Nu Modified by Adding 2% Mineral Oil and 2.5% Dowanol EP with Cover Letter.
||Dow Chemical Co., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Eye irritation ;
Skin irritation ;
Laboratory animals ;
Dow Chemical Corporation ;
CAS No 71-55-6 ;
Mineral oil ;
Primary dermal irritation ;
Primary eye irritation
||Some EPA libraries have a fiche copy filed under the call number shown.
||Samples of the old formulation of Chlorothene plus mineral oil or Dowanol EF were submitted for toxicological comparison with Chlorothene. Chlorothene NU plus 2.5% Dowano1 EP was also submitted. It was postulated that possibly the addition of the lubricants would reduce the whitening of the skin which occurs when Chlorothene is in contact for extended periods of time. The results are summarized in the table. As you can see the results indicate no practical difference in response from the modified samples which would recommend their use over the unmodified samples. Hence, if the customer wants the formulations with mineral oil or Dowanol EP there seems to be no reason not to supply them although it seems doubtful it will reduce the irritation produced by prolonged contact with the solvent.
||The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with American Petroleum Inst., Washington, DC.
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|PUB Date Free Form
||29 Jun 1984
||PC A12/MF A12