| Main Title |
Nine 'In Vitro Mutagenesis Studies' and Three 'Salmonella/Microsome (AMES) Bacterial Studies' with Cover Letter dated 07/28/1988. |
| CORP Author |
Mellon Inst.-Union Carbide Corp., Export, PA. Bushy Run Research Center.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1988 |
| Report Number |
FYI-OTS-0888-0630 |
| Stock Number |
OTS0000630 |
| Additional Subjects |
Toxicology ;
Health effects ;
Ethyleneamines ;
Acute toxicity ;
Geotoxicity ;
Gene mutations ;
Mammals ;
Hamsters ;
In vitro ;
DNA effects ;
Rats ;
Chromosomal effects ;
Bacteria ;
Mice ;
Parenteral ;
Intraperitoneal ;
CAS No 112-24-3 ;
CAS No 112-57-2 ;
CAS No 140-31-8 ;
CAS No 27308-78-7
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0000630 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
535p |
| Abstract |
Tetraethylenepentamine (TEPA) was evaluated for potential mutagenic activity with a battery of three in vitro tests, which were: the Chinese Hamster Ovary (CHO) Uutation test, the Sister Chromatid Exchange (SCE) test and an assay for induction of Unscheduled DNA Synthesis (UDS) in rat liver cells. The results indicated that the sample of TEPA produced a significant effect on primary DNA damagge assessed in the ECE and UDS tests but TEPA did not increase the frequency of gene mutations in the CHO Mutation test. The observation of a positive response in two of the three tests suggested that the complex mixture containing TEPA should be considered a weakly active mutagenic agent for mammalian cells in vitro. Because this sanple was a mixture which contained numerous other components, the present tests cannot discriminate whether TEPA itself or one or more components produced the positive responses. These results should be considered an indication of the potential activity of this material and they suggest the need for other tests to investigate the biological significance of the observations of this study. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
2 Aug 1988 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A24/MF A24 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028702330 |
| Origin |
NTIS |
| Type |
CAT |
