| Main Title |
Mutagenicity of Dimethyl Phthalte in a Mouse Lymphoma Mutation Assay (Final Report). |
| CORP Author |
Hazleton Biotechnologies, Kensington, MD.; Chemical Manufacturers Association, Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1986 |
| Report Number |
40-8626244 |
| Stock Number |
OTS0510741 |
| Additional Subjects |
Toxicology ;
Health effects ;
Bis(2-ethylhexyl)terephthalate ;
Genotoxicity ;
Gene Mutations ;
Mammals ;
Mice ;
In Vitro ;
Toxic substances ;
Laboratory animals ;
CAS No 131-11-3
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0510741 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
26p |
| Abstract |
The ability of dimethyl phthalate to induce specific locus mutations at the TK locus in cultured L5178Y mouse lymphoma cells (Mouse Lymphoma Mutagenicity Assay) was evaluated in the presence and absence of Aroclor-induced rat liver S9 metabolic activation. Dimethyl phthalate, diluted with acetone, was incompletely soluble at concentrations above 700 nl/ml without activation and above 500 nl/ml in the presence of metabolic activation. Non- activated cultures treated in duplicate with 200, 300, 400, 500, and 600 nl/ml produced a range of 101.7 to 52.5% relative growth. Since highly toxic treatments were not achieved, a second trialwith 8 non-activated cultures were treated in duplicate with 400, 500, 650, and 700 nl/ml, producing a range of 98.1 to 26.9% relative growth. S9 activated cultures treated in duplicate with 100, 200, 400, 500, and 600 nl/ml produced a range of 80.3 to 14.0% relative growth. Non-activated cultures at 500 nl/ml and 650 nl/ml produced mutant frequencies significantly greater than the solvent control (acetone); however, a dose-dependent response was not observed. All of the activated cultures produced mutant frequencies significantly greater than the solvent control. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Chemical Manufacturers Association, Washington, DC. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1986 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801620 |
| Origin |
NTIS |
| Type |
CAT |
