| Main Title |
L5178y Tk+/- Mouse Lymphoma Mutagenesis Assay with Confirmation Test Article Oleylamine. Final Report with Cover Letter dated 10/03/1989. |
| CORP Author |
Chemical Manufacturers Association, Washington, DC.; Microbiological Associates, Bethesda, MD.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1989 |
| Report Number |
FYI-AX-1089-0391 |
| Stock Number |
OTS0000391-1 |
| Additional Subjects |
Toxicology ;
Health effects ;
Oleylamine ;
Genotoxicity ;
Gene mutations ;
Mammals ;
Mice ;
In vitro ;
CAS No 112-90-3
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0000391-1 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
69p |
| Abstract |
The ability of oleylamine to induce specific locus mutations at the TK locus in cultured L5178Y mouse lymphoma cells (Mouse Lymphoma Mutagenesis Assay) was evaluated both in the presence and absence of metabolic activation from Aroclor-induced rat liver S9 fraction. Based on preliminary toxicity tests, 10 non-activated cultures treated with 0.13, 0.18, 0.24, 0.32, 0.42, 0.56, 0.75, 1.0, 1.3, or 1.8 nl/ml produced a range of 3-110% total growth. Eight activated cultures treated with 1.3, 1.8, 2.4, 3.2, 4.2, 5.6, 7.5, or 10 nl/ml produced a range of 6-106% total growth. Mutant frequencies in all treated cultures were less than 2 times that of the solvent (DMSO, acetone) controls, either with or without metabolic activation. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
Oct 1989 |
| Category Codes |
57Y; 57U; 68G; 99; 48G |
| NTIS Prices |
PC A05/MF A05 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010500420 |
| Origin |
NTIS |
| Type |
CAT |
