||Initial Submission: Acute Toxicity Studies with Epi-Cure 82 with Cover Letter dated 10/30/1992.
||Industrial Bio-Test Labs., Inc., Northbrook, IL.; Rhone-Poulenc Ag Co., Research Triangle Park, NC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Epi-Cure 82 ;
Acute toxicity ;
Primary eye irritation ;
Primary dermal irritation ;
CAS No 111-40-0 ;
CAS No 31326-29-1
||Some EPA libraries have a fiche copy filed under the call number shown.
||In an acute oral toxicity study, hypoactivity, muscular weakness, diarrhea, and ruffed fur were observed in animals surviving to study termination. At doses producing 90 to 100% mortality, labored breathing, convulsions, ptosis, and prostration were observed in addition to the clinical signs noted at a sublethal dose. The acute oral LD50 was approximately 540 mg/kg. In the dermal toxicity study, the test material was severely irritating to the skin of albino rabbits at all dose levels. Red, well-defined erythema, moderate to severe edema, subdermal hemorrhages, third degree burns, and necrosis were observed. Animals dosed at a lethal dose of 2000 mg/kg exhibited hypoactivity, muscular weakness, ataxia, loss of right reflex, tremors, prostration, and blood in the urine. In the eye irritation test, the material was found to be corrosive. Corrosion, loss of lens, and chemical burns were seen in all animals. Third degree burns were also observed in the dermal irritation study. The pH of the product is not known.
||The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
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|PUB Date Free Form
||20 Oct 1992
||57Y; 57U; 68G; 99; 44G
||PC A04/MF A04