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Main Title Initial Submission: Acute Toxicity Studies with Epi-Cure 82 with Cover Letter dated 10/30/1992.
CORP Author Industrial Bio-Test Labs., Inc., Northbrook, IL.; Rhone-Poulenc Ag Co., Research Triangle Park, NC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1992
Report Number 8EHQ-1092-11617
Stock Number OTS0571545
Additional Subjects Toxicology ; Health effects ; Epi-Cure 82 ; Acute toxicity ; Mammals ; Rats ; Oral ; Gavage ; Primary eye irritation ; Rabbits ; Dermal ; Primary dermal irritation ; CAS No 111-40-0 ; CAS No 31326-29-1
Library Call Number Additional Info Location Last
NTIS  OTS0571545 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 33p
Abstract In an acute oral toxicity study, hypoactivity, muscular weakness, diarrhea, and ruffed fur were observed in animals surviving to study termination. At doses producing 90 to 100% mortality, labored breathing, convulsions, ptosis, and prostration were observed in addition to the clinical signs noted at a sublethal dose. The acute oral LD50 was approximately 540 mg/kg. In the dermal toxicity study, the test material was severely irritating to the skin of albino rabbits at all dose levels. Red, well-defined erythema, moderate to severe edema, subdermal hemorrhages, third degree burns, and necrosis were observed. Animals dosed at a lethal dose of 2000 mg/kg exhibited hypoactivity, muscular weakness, ataxia, loss of right reflex, tremors, prostration, and blood in the urine. In the eye irritation test, the material was found to be corrosive. Corrosion, loss of lens, and chemical burns were seen in all animals. Third degree burns were also observed in the dermal irritation study. The pH of the product is not known.
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PUB Date Free Form 20 Oct 1992
Category Codes 57Y; 57U; 68G; 99; 44G
NTIS Prices PC A04/MF A04
Document Type NT
Cataloging Source NTIS/MT
Control Number 028700580
Origin NTIS
Type CAT