| Main Title |
Acute Toxicity Report for Test Substance o-dichlorobenzene; 98% Technical. |
| CORP Author |
Rohm and Haas Co., Bristol, PA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1979 |
| Report Number |
878212184 |
| Stock Number |
OTS0205976 |
| Additional Subjects |
Toxicity ;
Health effects ;
Chlorinated benzenes ;
Acute toxicity ;
Mammals ;
Rats ;
Parenteral ;
Subcutaneous ;
CAS No 95-50-1 ;
CAS No 108-90-7
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0205976 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
103p |
| Abstract |
Acute toxicity was evaluated in groups of 3 male CRCD rats receiving single doses of o-dichlorobenzene by subcutaneous intra-scapular injection at levels of 0.04, 0.2, 1.0, 5.0, 10.0, 19.0, 37.0 or 74.0 g/kg body weight. Mortality was observed in all animals receiving test article at dose levels of 10 mg/kg or higher (within 4 days of dosing), and the LD50 was reported to be between 5.0 and 10.0 g/kg. Clinical observations included yellow stained anogenital areas, passiveness, slow deep respiration, loss of righting reflex, ataxia, red stained eyes, salivation, lethargy, lacrimation, prostration, tremors, moribund, ptosis and clonic convulsions. Gross necropsy of decedents revealed slight to moderately red lungs, while no visible lesions or gross changes were observed in survivors at 14 days. Document includes: Acute Toxicity Report. O-dichlorobenzene Myelotoxicity & Cytogenetic Study in Rats. O-dichlorobenzene Microbial Mutagen Test. Mutagenicity Evaluation of O-dichlorobenzene Final Report. Mutagenicity Evaluation of Monochlorobenzene Final Report. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
Sep 1979 |
| Category Codes |
57Y; 57U; 68G; 99; 48G |
| NTIS Prices |
PC A07/MF A07 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010500580 |
| Origin |
NTIS |
| Type |
CAT |
