||Toxicological Review of Toluene (CAS No. 108-88-3) in Support of Summary Information on the Integrated Risk Information System (IRIS).
||Environmental Protection Agency, Washington, DC.
Environmental exposure pathway ;
Health hazards ;
Health effects ;
Risk assessment ;
Dose-response relationships ;
Hazardous substances ;
Chemical properties ;
Dermal absorption ;
Oral dosage ;
Chronic exposure ;
Chronic disease ;
CAS No 108-88-3 ;
Integrated Risk Information System(IRIS)
||Some EPA libraries have a fiche copy filed under the call number shown.
||This document presents background information and justification for the Integrated Risk Information System (IRIS) Summary of the hazard and dose-response assessment of toluene. IRIS Summaries may include an oral reference dose (RfD), inhalation reference concentration (RfC) and a carcinogenicity assessment. The RfD and RfC provide quantitative information for use in risk assessments for health effects known or assumed to be produced through a nonlinear (possibly threshold) mode of action. The RfD is an estimate of an oral exposure for (a given duration), to the human population (including susceptible subgroups) that is likely to be without an appreciable risk of adverse health effects over a lifetime. It is derived from a statistical lower confidence limit on the benchmark dose (BMDL), a no-observed-adverse effect-level (NOAEL), a lowest-observed-adverse-effect level (LOAEL), or another suitable point of departure, with uncertainty/variability factors applied to reflect limitations of the data used.
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||57Y; 57U; 68G