| Main Title |
Acute Oral Toxicity (ld50) in Rats with Cover Letter Dated 06/25/1987. |
| CORP Author |
Springborn Inst. for Bioresearch, Inc., Spencerville, OH.; Occidental Chemical Corp., Grand Island, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1987 |
| Report Number |
86870000414 |
| Stock Number |
OTS0513162 |
| Additional Subjects |
Toxicology ;
Health effects ;
1-chloro-4-methylbenzene (106-43-4) ;
Acute Toxicity ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Toxic substances ;
Laboratory animals ;
CAS No 106-43-4
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0513162 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
63p |
| Abstract |
Acute oral toxicity was evaluated in groups of 5 male and 5 female fasted Sprague-Dawley rats administered 4-chlorotoluene by gavage at a level of 1.7, 2.3, 3.3 or 4.6 g/kg. Mortality was observed in 2 males in the 1.7 g/kg group, 3 males and 4 females in the 2.3 g/kg group, and in all 5 males and females in the 3.3 and 4.6 g/kg groups. The LD50 was determined to be 2.1 g/kg (1.8 - 2.4 g/kg). Clinical observations included a decrease in motor activity, tremors, cyanosis, piloerection, excess salivation, chromodacryorrhea, increase in respiratory rate, decrease in respiratory rate and lacrimation. Gross necropsy revealed brightred or red and mottled lungs, stomach and intestinal irritation and cream colored, white or dark fluid in the stomach and intestine, red stained fur around the nose, 'blanched' stomachs and fluid filled stomachs. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Occidental Chemical Corp., Grand Island, NY. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1987 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A05/MF A05 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801720 |
| Origin |
NTIS |
| Type |
CAT |
