| Main Title |
Butyraldehyde Vapor Inhalation by Dogs and Rats for 14 and 23 Weeks Respectively and a 12 Week Vapor Inhalation Study in Rats with Attached Appendices and Cover Letter dated 02/22/88. |
| CORP Author |
Carnegie-Mellon Inst. of Research, Pittsburgh, PA. ;Union Carbide Corp., Danbury, CT.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
20 Oct 1988 |
| Year Published |
1988 |
| Report Number |
FYI-OTS-1088-0647D; |
| Stock Number |
OTS-0000647 |
| Additional Subjects |
Butyraldehyde ;
Toxicity ;
Inhalation ;
Dogs ;
Rats ;
Vapors ;
Toxic response ;
Respiratory tract ;
Nasal mucosa ;
Toxicology ;
Health effects ;
Union Carbide(Trademark)
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0000647 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
102p |
| Abstract |
Male beagle dogs and male and female Sprague-Dawley rats were exposed 6 hours per day, 5 days per week for up to 14 and 13 weeks, respectively, to butyraldehyde vapor concentrations of 5.44, 1.36, and 0.34 mg/liter (2000, 500 and 125 ppm). The measured parameters for toxic response included body and organ weights, urinalysis, food chemistry, pathology, ophthalmologic and hematologic examinations. Rats at all levels tested had a significant incidence of aquamous metaplasia of the nasal cavities. Dogs exposed to 2000 ppm had significant microscopic lesions of the upper respiratory tract, including mucosal cell hyperplasia, inflammation, and mucous metaplasia. Exposed dogs at 500 and 125 ppm had goblet cell hyperplasia within the nasal mucosa. There were no other significant differences found between test and control groups which could be related to inhalation of butyraldehyde vapor concentrations. This study was designed to examine toxic response in dogs and rats subjected to repeated inhalation of atmospheres containing butyraldehyde vapor. All raw data are being held at the Chemical Hygiene Laboratory of Carnegie-Mellon Institute of Research for future reference. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with American Petroleum Inst., Washington, DC. |
| Availability Notes |
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| Category Codes |
57Y |
| NTIS Prices |
PC A07/MF$25.00 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
019102990 |
| Origin |
NTIS |
| Type |
CAT |
