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OLS Field Name OLS Field Data
Main Title Chemical and Radiation Leukemogenesis in Humans and Rodents and the Value of Rodent Models for Assessing Risks of Lymphohematopoietic Cancers.
Author Eastmond, D. A. ;
CORP Author Calilfornia Univ., Riverside. Environmental Toxicology Graduate Program.;Environmental Protection Agency, Washington, DC. National Center for Environmental Assessment.
Publisher May 97
Year Published 1997
Report Number NCEA-W-0275 ; EPA/600/R-97/090
Stock Number PB97-208185
Additional Subjects Leukemogenesis ; Chemical warfare agents ; Ionizing radiation ; Genetic effects ; Bioassay ; Animal models ; Mice ; Rats ; Toxic substances ; Alkylating agents ; Podophyllotoxin ; Benzene ; Butadienes ; Exposure ; Chromosomal aberrations ; Genetic radiation effects ; Hematopoiesis ; Leukopoiesis ; Lymphotcytes ; Leukemia ; Neoplasms ; Inhibitors ; Humans ; Dioxopiperazine
Library Call Number Additional Info Location Last
NTIS  PB97-208185 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 12/22/1997
Collation 131p
Abstract This report is intended to provide an up-to-date overview of the lymphoid and hematopietic diseases induced in humans and rodents following exposure to chemical agents. It includes a brief introduction to hematopoiesis and lymphopoiesis in humans and rodents, selected characteristics of known leukemia-inducing agents and their effects in mice and rats are compared and the value of rodents models. Six different classes of established leukemia-inducing agents were included: in ionizing radiation, alkylatingagents, epipodophyllotoxin-type topoisomerase inhibitors, dioxopiperazine-type topoisomerase inhibitors, benzene, and 1,3 butadiene. The current understanding of mechanisms underlying acute nonlymphocytic leukemia in humans and thymic lymphoma and myeloid leukemia in mice is presented. The relevance of mouse models for human leukemias and lymphomas is discussed. Furthermore, chronic animal bioassays using mouse models have been shown to be effective in identifying human leukemia-inducing agents.
Supplementary Notes Sponsored by Environmental Protection Agency, Washington, DC. National Center for Environmental Assessment.
Availability Notes Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)321-8547; and email at orders@ntis.fedworld.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA.
Category Codes 57F; 57O; 57Y
NTIS Prices PC A08/MF A02
Primary Description 600/21
Document Type NT
Cataloging Source NTIS/MT
Control Number 731602890
Origin NTIS
Type CAT