| Main Title |
Effect of 5-Azacytidine Administration during Very Early Pregnancy. |
| Author |
Cummings, A. M. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Reproductive Toxicology Branch. |
| Publisher |
cOct 94 |
| Year Published |
1994 |
| Report Number |
EPA/600/J-94/519; |
| Stock Number |
PB95-148813 |
| Additional Subjects |
Azacytidine ;
Pregnancy ;
Teratogens ;
Toxicity ;
Pregnancy outcome ;
Body weight ;
Congenital abnormalities ;
Preimplantation phase ;
Postimplantation phase ;
Fetus ;
Microphthalmos ;
Dose-response relationships ;
Reprints ;
Exencephaly
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB95-148813 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
7p |
| Abstract |
The chemotherapeutic agent 5-azacytidine (5AZ) is cytotoxic via nucleic acid hypomethylation. Malformations and embryo-lethality result when rats or mice are exposed to 5AZ on any of Days 9 through 12 of pregnancy. To investigate the effect of 5AZ exposure during the pre- and early postimplantation period, we administered 0.15, 0.30, 0.60, or 1.2 mg/kg 5AZ/day to rats during Days 1-8 of pregnancy and evaluated outcome on Days 9 or 20. No adverse effects were detected on Day 9; the numbers and weights of implantation sites, the numbers of resorptions, maternal body weight gains, and hormone measures were not different from those of controls. However, when pregnancy outcome was evaluated on Day 20, dose-dependent decreases in offspring survival and fetal weight were observed and the incidences of two malformations, microphthalmia and exencephaly, were increased. (Copyright (c) 1994 Society of Toxicology.) |
| Supplementary Notes |
Pub. in Fundamental and Applied Toxicology, v23 n3 p429-433 Oct 94. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Effect of 5-Azacytidine Administration during Very Early Pregnancy. |
| Category Codes |
57Y; 57S |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
503415306 |
| Origin |
NTIS |
| Type |
CAT |
