Main Title |
Acute Effects of Amitraz on the Acoustic Startle Response and Motor Activity. |
Author |
Crofton, K. M. ;
Boncek, V. M. ;
Reiter., L. W. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;Northrop Services, Inc., Research Triangle Park, NC. |
Publisher |
c1989 |
Year Published |
1989 |
Report Number |
EPA/600/J-89/468; |
Stock Number |
PB91-115998 |
Additional Subjects |
Pesticides ;
Animal behavior ;
Acoustics ;
Body temperature ;
Body weight ;
Rats ;
Mortality ;
Reprints ;
Amitraz ;
Motor activity ;
Startle reaction ;
Dose-response relationships
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB91-115998 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
13p |
Abstract |
To characterize further the behavioral toxicity of amitraz, comparisons were made between the effects of amitraz on motor activity, the acoustic startle response, body temperature, and body weight in male Long-Evans rats. Acute dosage-effect and time-course determinations of motor activity were made using figure-eight mazes. Dosage-effect and time-course determinations for the acoustic startle response were measured using a 13 KHZ, 120 dB(A), 40 ms tone as the eliciting stimulus, at each of three background white-noise levels. Amitraz was administered orally in the vehicle ('Emulphor'+ethanol+saline,d a dosage- and time-dependent decrease in motor activity which lasted from 4 to 96 h post-administration. The effects of amitraz on the acoustic startle response consisted of an increased latency and a decreased amplitude and sensitization. The time-course of effects on the acoustic startle response were more transient (4-24 h) than the effects on motor activity. Amitraz-exposed animals had decreased body weight that did not return to control levels until 120 h (five days) post-administration. (Copyright (c) 1989 Society of Chemical Industry.) |
Supplementary Notes |
Pub. in Pesticide Science, v27 n1 p1-11 Aug 89. Prepared in cooperation with Northrop Services, Inc., Research Triangle Park, NC. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Acute Effects of Amitraz on the Acoustic Startle Response and Motor Activity. |
Category Codes |
57Y; 57S; 68E |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
101123348 |
Origin |
NTIS |
Type |
CAT |