Main Title |
Subchronic 90 Day Toxicity of Dichloroacetic and Trichloroacetic Acid in Rats. |
Author |
Mather, G. G. ;
Exon, J. H. ;
Koller, L. D. ;
|
CORP Author |
Idaho Univ., Moscow. ;Oregon State Univ., Corvallis. School of Veterinary Medicine.;Health Effects Research Lab., Research Triangle Park, NC. |
Publisher |
c1990 |
Year Published |
1990 |
Report Number |
EPA/600/J-90/425; |
Stock Number |
PB91-171801 |
Additional Subjects |
Toxicity ;
Dichloroacetate ;
Trichloroacetic acid ;
Dose-response relationships ;
Mixed function oxidases ;
Blood proteins ;
Organ weight ;
Body weight ;
Alkaline phosphatase ;
Alanine aminotransferase ;
Pathology ;
Immune system ;
Statistical analysis ;
Blood chemistry ;
Enzyme induction ;
Reprints ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB91-171801 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
12p |
Abstract |
Male Sprague-Dawley rats were treated with either dichloroacetic acid (DCA) or trichloroacetic acid (TCA) in the drinking water at levels of 0, 50, 500 and 5000 ppm for a period of 90 days to determine the toxicities associated with subchronic exposure. All animals were sacrificed and examined for gross and histopathologic lesions, serochemical changes, immune dysfunction, hepatic peroxisomal and mixed function oxidase enzyme induction and organ-body weight changes. Animals treated with DCa had decreased body weight gains (500 and 5000 ppm) and decreased total serum protein (all doses). Rats given either TCA (5000 ppm) or DCA (500 or 5000 ppm) had increased liver and kidney organ to body weight ratios. Rats offered DCA had significantly elevated alkaline phosphatase (500 and 5000 ppm) and alanine-amino transferase (5000 ppm). No consistent immunotoxicity was observed in animals exposed to either compound. Rats treated with 5000 ppm TCA or DCA had significantly increased hepatic peroxisomal beta-oxidation activity. (Copyright (c) 1990 Elsevier Scientific Publishers Ireland Ltd.) |
Supplementary Notes |
Pub. in Toxicology, v64 n1 p71-80 Oct 90. Prepared in cooperation with Oregon State Univ., Corvallis. School of Veterinary Medicine. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Subchronic 90 Day Toxicity of Dichloroacetic and Trichloroacetic Acid in Rats. |
Category Codes |
57Y; 68G |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
114324847 |
Origin |
NTIS |
Type |
CAT |