| Main Title |
MTBE: Repeated (13-Week) Vapor Inhalation Study in Rats with Neurotoxicity Evaluation and MTBE: Single Exposure Vapor Inhalation Neurotoxicity Study in Rats with Attachments and Letter. |
| CORP Author |
Mellon Inst.-Union Carbide Corp., Export, PA. Bushy Run Research Center.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
30 Oct 1989 |
| Year Published |
1989 |
| Report Number |
FYI-OTS-1189-0689; |
| Stock Number |
OTS-0000689-3 |
| Additional Subjects |
Rats ;
Neurotoxicity ;
Exposure ;
Body weight ;
Food consumption ;
Nervous system ;
Motor activity ;
Vapor inhalation ;
Methyl tertiary butyl ether ;
Fischer 344 rats ;
Hematologic analysis ;
Serum chemistry
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0000689-3 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
820p |
| Abstract |
Four groups, each consisting of 25 male and 25 female Fischer 344 rats, were exposed 6 hours per day, 5 days per week, for 13 weeks to vapor of methyl tertiary butyl ether (MTBE) at target concentrations of 8000, 400, 800, or 0 (control) ppm. The 8000 ppm concentration was chosen as the high exposure level due to the explosive nature of MTBE. The Environmental Protection Agency in the Section 4 Consent Order agreed to limit the high exposure level to 502 of the lower explosion limit for MTBE (i.e., 8000 ppm). Monitors for toxicity were as follows: daily clinical observations; function observational batted on study weeks 1, 2, 4, 8, and 13. Motor activity on study weeks 4, 8, and 13 body weights; food consumption; hematological analyses; serum chemistry including selected adrenal hormonal analyses: organ weights; and ophthalmic, gross pathologic, and microscopic evaluations. Detailed microscopic evaluations were performed on the nervous system of selected rats (6/sex/group) following perfusion fixation of tissues. |
| Supplementary Notes |
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| Availability Notes |
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| Category Codes |
57 |
| NTIS Prices |
PC A99/MF E08 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
019103410 |
| Origin |
NTIS |
| Type |
CAT |
