| Main Title |
Hypothermic Effects of a Homologous Series of Short-Chain Alcohols in Rats. |
| Author |
Mohler, F. S. ;
Gordon, C. J. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. |
| Publisher |
c1991 |
| Year Published |
1991 |
| Report Number |
EPA/600/J-91/044; |
| Stock Number |
PB91-191510 |
| Additional Subjects |
Toxicity ;
Body temperature regulation ;
Hypothermia ;
Propanol ;
Butanol ;
Rats ;
Dose-response relationships ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB91-191510 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
13p |
| Abstract |
The purpose of the study was to assess the toxicity of various short-chain alcohols using the thermoregulatory system of the rat as an endpoint. Male Fischer rats developed significant hypothermia following acute administration (i.p.) of methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, or 2-butanol. The hypothermic responses to the six alcohols all showed similar bimodal responses characterized by a threshold dose below which no change in body temperature occurred, and a suprathreshold regression with increasing dose causing greater hypothermia. Relative efficacy of the alcohols was compared using both the threshold dose to cause hypothermia and the dose which would cause body temperature to decrease by 1 C. Both measures gave the progression of toxicity from least to most potent of: methanol
|
| Supplementary Notes |
Pub. in Jnl. of Toxicology and Environmental Health, v32 n2 p129-139 1991. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Hypothermic Effects of a Homologous Series of Short-Chain Alcohols in Rats. |
| Category Codes |
57Y; 57S |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
119326256 |
| Origin |
NTIS |
| Type |
CAT |
