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Main Title Disposition of 14C and/or 74As-Cacodylic Acid in Rats After Intravenous, Intratracheal, or Peroral Administration.
Author Stevens, J. T. ; Hall, L. L. ; Farmer, J. D. ; DiPasquale, L. C. ; Chernoff., N. ;
CORP Author Health Effects Research Lab., Research Triangle Park, N.C. Environmental Toxicology Div.
Year Published 1977
Report Number EPA/600/J-77/107;
Stock Number PB-278 450
Additional Subjects Bioassay ; Pesticides ; Herbicides ; Arsenic organic compounds ; Toxicology ; Absorption(Biology) ; Metabolism ; Excretion ; Dosage ; Parenteral infusions ; Rats ; Laboratory animals ; Ingestion(Biology) ; Concentration(Composition) ; Blood ; Tissues(Biology) ; Muscles ; Kidney ; Liver ; Lung ; Labeled substances ; Erythrocytes ; Reprints ; Cacodylic acid ; Pesticide residues ; Gavage ; Body burdens ; Bioaccumulation
Library Call Number Additional Info Location Last
NTIS  PB-278 450 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
Abstract The distribution, excretion, and possible metabolism of (14)C- and/or (74)As-cacodylic acid, and organoarsenical herbicide, was studied in rats following a single intravenous injection, intratracheal instillation or oral gavage. Male Sherman rats were dosed at levels ranging from 200 mg/kg to 120 micrograms/kg. The extent and rate of lung absorption was greater than gastrointestinal absorption. Concentrations in the liver and whole blood were higher after peroral dosing than intravenous administration. Levels observed in plasma and other tissues were similar after all three routes following the absorptive phase. The percent dose found in the whole blood, red blood cells, and plasma was similar for all doses given by these routes. Less than 0.1-1/2 of the administered dose was recovered as (14)CO2 by any route at 24 hr after administration. Levels in all tissues decreased rapidly, but remained high in whole blood. The red blood cells were found to be the major site of body burden of cacodylic acid.
Supplementary Notes Pub. in Environmental Health Perspectives, v19 p151-157 1977.
NTIS Title Notes Journal article.
Title Annotations Reprint: Disposition of 14C and/or 74As-Cacodylic Acid in Rats After Intravenous, Intratracheal, or Peroral Administration.
PUB Date Free Form Aug 77
Category Codes 6T; 6F; 57Y; 57H; 68G; 68E
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 323736579
Origin NTIS
Type CAT