| Main Title |
Polar Narcosis in Aquatic Organisms. |
| Author |
Bradbury, S. P. ;
Carlson, R. W. ;
Henry, T. R. ;
|
| CORP Author |
Environmental Research Lab., Duluth, MN. ;American Scientific International, Duluth, MN. |
| Publisher |
c1989 |
| Year Published |
1989 |
| Report Number |
EPA/600/D-89/177; |
| Stock Number |
PB90-116062 |
| Additional Subjects |
Aquatic biology ;
Polarity ;
Narcosis ;
Blood chemical analysis ;
Respiration ;
Blood circulation ;
Reprints ;
Water pollution effects(Animals) ;
Toxic substances ;
Structure-activity relationship ;
Synergism
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB90-116062 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
18p |
| Abstract |
The majority of industrial organic chemicals lack identifiable structural characteristics that result in specific biological activity. These nonpolar-nonelectrolytes are acutely toxic to aquatic organisms via a nonspecific mode of action termed narcosis. The toxicity of industrial chemicals eliciting nonpolar narcosis can be reliably predicted by log P (baseline toxicity models). Using single chemical and joint toxic action models, several research groups have reported classes of polar compounds (for example, esters, phenols, and anilines) that elicit a narcosis-like syndrome; however, they are more acutely toxic than what is predicted using baseline toxicity models. An assessment of rainbow trout (Salmo gairdneri) in vivo respiratory-cardiovascular responses during intoxication by polar narcotic phenol and aniline derivatives established a toxicity syndrome unique to that elicited by nonpolar narcotics. The finding further suggests a mode of action unique to polar narcotics and supports the use of structure-activity relationships specific for these compounds. (Copyright (c) American Society for Testing and Materials.) |
| Supplementary Notes |
Pub. in Aquatic Toxicology and Hazard Assessment, v12 p59-73 1989. Prepared in cooperation with American Scientific International, Duluth, MN. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Polar Narcosis in Aquatic Organisms. |
| Category Codes |
68D; 57Y; 48G |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
935222125 |
| Origin |
NTIS |
| Type |
CAT |
